EXPOSURE TO ANTHRAX IN PREGNANCY

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(Date of issue: June 2018, Version: 1.3)

This is a UKTIS monograph for use by health care professionals. For case-specific advice please contact UKTIS on 0344 892 0909. To report an exposure please download and complete a pregnancy reporting form. Please encourage all women to complete an online reporting form.

Summary

Anthrax is a bacterial infection caused by Bacillus anthracis. Morbidity and mortality following infection are high and rapid treatment following exposure is therefore required.  When clinically indicated, the pregnant patient should be treated as for the non-pregnant patient. Ciprofloxacin is the first-line treatment for anthrax.  Amoxicillin may also be used for treatment or prophylaxis but only if the specific strain is known to be penicillin-sensitive.

Published human data regarding maternal anthrax infection are limited to 18 case reports of infection in the latter half of pregnancy. Preterm delivery following maternal anthrax infection was reported in three of the cases even after successful treatment of the maternal infection.  Intrauterine death preceded maternal death in three cases.

There are no published reports of fetal outcome following anthrax infection in the first trimester of pregnancy and an evidence-based assessment of malformation risk following exposure during this period is thus not possible. The need for additional fetal monitoring should be considered on a case-by-case basis. Discussion with UKTIS is recommended in all cases.

This document is regularly reviewed and updated. Only use full UKTIS monographs downloaded directly from TOXBASE.org to be sure you are using the most up-to-date version. The summaries of these monographs are openly available on UKTIS.org.

This is a summary of the full UKTIS monograph for health care professionals and should not be used in isolation. The full UKTIS monograph and access to any hyperlinked related documents is available to health care professionals at www.toxbase.org.

If you have a patient with exposure to a drug or chemical and require assistance in making a patient-specific risk assessment, please telephone UKTIS on 0344 892 0909 to discuss the case with a teratology specialist.

If you would like to report a pregnancy to UKTIS please click here to download our pregnancy reporting form. Please encourage all women to complete an online reporting form.

Disclaimer: Every effort has been made to ensure that this monograph was accurate and up-to-date at the time of writing, however it cannot cover every eventuality and the information providers cannot be held responsible for any adverse outcomes of the measures recommended. The final decision regarding which treatment is used for an individual patient remains the clinical responsibility of the prescriber. This material may be freely reproduced for education and not for profit purposes within the UK National Health Service, however no linking to this website or reproduction by or for commercial organisations is permitted without the express written permission of this service. This document is regularly reviewed and updated. Only use UKTIS monographs downloaded directly from TOXBASE.org or UKTIS.org to ensure you are using the most up-to-date version.