USE OF ADENOSINE IN PREGNANCY

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(Date of issue: November 2016, Version: 2.1)

This is a UKTIS monograph for use by health care professionals. For case-specific advice please contact UKTIS on 0344 892 0909. To report an exposure please download and complete a pregnancy reporting form. Please encourage all women to complete an online reporting form.

Summary

Adenosine is an endogenous nucleoside present in all cells of the body. Exogenous adenosine is used in the acute management of paroxysmal supraventricular tachycardias (SVT), including those associated with accessory-conduction pathways (e.g. Wolff-Parkinson-White syndrome). Adenosine has also been used to treat fetal arrhythmias.

There is extremely limited experience regarding exogenous adenosine use in human pregnancy, with most reported exposures occurring in the second and third trimesters. Adverse fetal outcomes have been occasionally reported following use of adenosine in the management of maternal and fetal arrhythmias. However, these were most likely related to the maternal or fetal condition for which treatment with adenosine was indicated, rather than being a direct consequence of adenosine exposure.

Left untreated, maternal SVT may have detrimental effects on both the mother and the fetus. If clinically indicated, adenosine should not be withheld on account of pregnancy.

Exposure to adenosine at any stage of pregnancy would not usually be regarded as medical grounds for termination of pregnancy or any additional fetal monitoring. However, other risk factors may be present in individual cases which may independently increase the risk of adverse pregnancy outcome. Clinicians are reminded of the importance of consideration of such factors when performing case-specific risk assessments.
                      
This document is regularly reviewed and updated. Only use full UKTIS monographs downloaded directly from TOXBASE.org to be sure you are using the most up-to-date version. The summaries of these monographs are openly available on UKTIS.org.

This is a summary of the full UKTIS monograph for health care professionals and should not be used in isolation. The full UKTIS monograph and access to any hyperlinked related documents is available to health care professionals at www.toxbase.org.

If you have a patient with exposure to a drug or chemical and require assistance in making a patient-specific risk assessment, please telephone UKTIS on 0344 892 0909 to discuss the case with a teratology specialist.

If you would like to report a pregnancy to UKTIS please click here to download our pregnancy reporting form. Please encourage all women to complete an online reporting form.

Disclaimer: Every effort has been made to ensure that this monograph was accurate and up-to-date at the time of writing, however it cannot cover every eventuality and the information providers cannot be held responsible for any adverse outcomes of the measures recommended. The final decision regarding which treatment is used for an individual patient remains the clinical responsibility of the prescriber. This material may be freely reproduced for education and not for profit purposes within the UK National Health Service, however no linking to this website or reproduction by or for commercial organisations is permitted without the express written permission of this service. This document is regularly reviewed and updated. Only use UKTIS monographs downloaded directly from TOXBASE.org or UKTIS.org to ensure you are using the most up-to-date version.