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EXPOSURE TO ETHYLENE GLYCOL MONOBUTYL ETHER IN PREGNANCY

Date of issue: May 2011
Version: 1

This is a UKTIS monograph for use by health care professionals. For case-specific advice please contact UKTIS on 0344 892 0909. To report an exposure please download and complete a pregnancy reporting form. Please encourage all women to complete an online reporting form.

Summary

Ethylene glycol monobutyl ether (EGBE) is used in hydraulic fluids, as a coupling agent for water-based coatings, in vinyl and acrylic paints, and as a solvent for varnishes, enamels, spray lacquers, dry cleaning compounds, textiles and cosmetics.

There are no published data regarding exposure to EGBE during human pregnancy, and animal data has not demonstrated teratogenicity in the absence of maternal toxicity.

As with all chemicals, unnecessary exposure to EGBE should be avoided during pregnancy.  However, where occupational exposure is unavoidable then precautions should be taken to ensure that exposure is well within the recommended exposure limits and not associated with toxic symptoms.

Data following acute exposure are limited, however in the absence of severe maternal toxicity the risks of fetal toxicity appear to be no greater than those for the general population.  When systemic toxicity occurs following exposure, it is important to treat the mother appropriately to reduce the risks of both maternal and fetal toxicity.  Inadvertent exposure would not usually be regarded as medical grounds for termination of pregnancy or additional prenatal diagnostic tests.

Note: This document has been archived and will not be routinely updated. If up-to-date information is required please contact UKTIS.

This document is regularly reviewed and updated. Only use full UKTIS monographs downloaded directly from TOXBASE.org to be sure you are using the most up-to-date version. The summaries of these monographs are openly available on UKTIS.org.

This is a summary of the full UKTIS monograph for health care professionals and should not be used in isolation. The full UKTIS monograph and access to any hyperlinked related documents is available to health care professionals at www.toxbase.org.

If you have a patient with exposure to a drug or chemical and require assistance in making a patient-specific risk assessment, please telephone UKTIS on 0344 892 0909 to discuss the case with a teratology specialist.

If you would like to report a pregnancy to UKTIS please click here to download our pregnancy reporting form. Please encourage all women to complete an online reporting form.

Disclaimer: Every effort has been made to ensure that this monograph was accurate and up-to-date at the time of writing, however it cannot cover every eventuality and the information providers cannot be held responsible for any adverse outcomes of the measures recommended. The final decision regarding which treatment is used for an individual patient remains the clinical responsibility of the prescriber. This material may be freely reproduced for education and not for profit purposes within the UK National Health Service, however no linking to this website or reproduction by or for commercial organisations is permitted without the express written permission of this service. This document is regularly reviewed and updated. Only use UKTIS monographs downloaded directly from TOXBASE.org or UKTIS.org to ensure you are using the most up-to-date version.