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(Date of issue: February 2019, Version: 3)

This is a UKTIS monograph for use by health care professionals. For case-specific advice please contact UKTIS on 0344 892 0909. To report an exposure please download and complete a pregnancy reporting form. Please encourage all women to complete an online reporting form.

A corresponding patient information leaflet on chloroquine use in pregnancy is available at


Chloroquine is used for chemoprophylaxis and treatment of malaria. It is also used in the treatment of amoebic hepatitis/abscess, lupus erythematosus and rheumatoid arthritis. This document covers data relating to use of chloroquine as an antimalarial only.

Travel to areas where malaria is endemic should be avoided during pregnancy wherever possible. If travel to such areas is unavoidable, insect repellents, bed nets, appropriate clothing to prevent mosquito bites and adequate chemoprophylaxis should be used.

Human pregnancy data relating to both prophylaxis and treatment with chloroquine provide no evidence that exposure to the medication itself increases the risk of miscarriage, congenital malformation or stillbirth/IUD, prematurity, growth restriction or neonatal complications, and no conclusive evidence of an increased risk of low birth weight. However, data for some of these outcomes is limited, particularly those related to first trimester/early pregnancy exposure. Due to the limitations of the available data, increased risks of congenital malformation or miscarriage cannot be completely excluded.

Where use of chloroquine is clinically indicated it should not be withheld on account of the pregnancy as the known risks of maternal malaria infection are likely to be far greater than any potential risks to the fetus from the drug.

Exposure to chloroquine at any stage of pregnancy in the absence of maternal malaria infection would not usually be regarded as an indication for additional fetal monitoring. However, other risk factors may be present in individual cases which independently increase the risk of an adverse pregnancy outcome. Clinicians are reminded of the importance of consideration of such factors when performing case-specific risk assessments.

NOTE: Please ensure that the selected antimalarial will provide appropriate prophylaxis for the area of travel. Up-to-date advice is available from a number of sources (e.g. BNF,[1] Fit For Travel,[2] NathNAC,[3] TRAVAX[4]).

For further advice on malaria prevention in pregnancy please refer to the relevant UKTIS document below.

This document is regularly reviewed and updated. Only use full UKTIS monographs downloaded directly from to be sure you are using the most up-to-date version. The summaries of these monographs are openly available on

This is a summary of the full UKTIS monograph for health care professionals and should not be used in isolation. The full UKTIS monograph and access to any hyperlinked related documents is available to health care professionals at

If you have a patient with exposure to a drug or chemical and require assistance in making a patient-specific risk assessment, please telephone UKTIS on 0344 892 0909 to discuss the case with a teratology specialist.

If you would like to report a pregnancy to UKTIS please click here to download our pregnancy reporting form. Please encourage all women to complete an online reporting form.

Disclaimer: Every effort has been made to ensure that this monograph was accurate and up-to-date at the time of writing, however it cannot cover every eventuality and the information providers cannot be held responsible for any adverse outcomes of the measures recommended. The final decision regarding which treatment is used for an individual patient remains the clinical responsibility of the prescriber. This material may be freely reproduced for education and not for profit purposes within the UK National Health Service, however no linking to this website or reproduction by or for commercial organisations is permitted without the express written permission of this service. This document is regularly reviewed and updated. Only use UKTIS monographs downloaded directly from or to ensure you are using the most up-to-date version.