USE OF PODOPHYLLIN IN PREGNANCY

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(Date of issue: June 2015, Version: 2)

This is a UKTIS monograph for use by health care professionals. For case-specific advice please contact UKTIS on 0344 892 0909. To report an exposure please download and complete a pregnancy reporting form. Please encourage all women to complete an online reporting form.

A corresponding patient information leaflet on podophyllin use in pregnancy is available at www.medicinesinpregnancy.org.

Summary

Podophyllin is derived from the roots of Podophyllum peltatum (mandrake or mayapple) and is used topically for the treatment of condylomata acuminata (genital warts).

The available data are too limited to allow an assessment of the safety of podophyllin use in pregnancy. Adverse fetal effects in pregnancy have been reported where maternal toxicity has occurred with oral podophyllin preparations, or where podophyllin has been applied topically in excessive amounts. Wherever possible, podophyllin treatment should be avoided in pregnancy due to lack of safety data.

There are no published guidelines on the management of podophyllin poisoning during pregnancy. Maternal toxicity is likely to be a major determinant of risk to the fetus and treatment should be as for the non-pregnant patient. However, due to a lack of data concerning the teratogenicity of podophyllin, it is not currently possible to state that an absence of maternal toxicity excludes the possibility of adverse effects of exposure on the developing fetus. Discussion with UKTIS is recommended in all cases.

This document is regularly reviewed and updated. Only use UKTIS monographs downloaded directly from TOXBASE.org or UKTIS.org to be sure you are using the most up-to-date version.

This is a summary of the full UKTIS monograph for health care professionals and should not be used in isolation. The full UKTIS monograph and access to any hyperlinked related documents is available to health care professionals at www.toxbase.org.

If you have a patient with exposure to a drug or chemical and require assistance in making a patient-specific risk assessment, please telephone UKTIS on 0344 892 0909 to discuss the case with a teratology specialist.

If you would like to report a pregnancy to UKTIS please click here to download our pregnancy reporting form. Please encourage all women to complete an online reporting form.

Disclaimer: Every effort has been made to ensure that this monograph was accurate and up-to-date at the time of writing, however it cannot cover every eventuality and the information providers cannot be held responsible for any adverse outcomes of the measures recommended. The final decision regarding which treatment is used for an individual patient remains the clinical responsibility of the prescriber. This material may be freely reproduced for education and not for profit purposes within the UK National Health Service, however no linking to this website or reproduction by or for commercial organisations is permitted without the express written permission of this service. This document is regularly reviewed and updated. Only use UKTIS monographs downloaded directly from TOXBASE.org or UKTIS.org to ensure you are using the most up-to-date version.